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L'inhibition de la DPP-4 entraîne une augmentation importante de la concentration de GLP-1 et de GIP qui provoquent une augmentation de la sécrétion d'insuline et une diminution de la sécrétion de glucagon, propriété permettant d'améliorer l'équilibre en sucre chez le diabétique.

Les gliptines font ainsi partie des molécules jouant sur l'augmentation du taux d'incrétine, les autres étant des analogues de cette dernière : exénatide et liraglutide.

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Our five aspirational operating principles focus on safety, environmental safeguards, and engagement with nearby communities to address concerns and help develop local economies.

We are working towards making all of our Shell-operated onshore projects where hydraulic fracturing is used, to produce gas and oil from tight sandstone or shale, consistent with these principles.

Our expertise means we can help and advise customers develop their new products (NPI), focusing on cost, quality and on-time delivery.

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Our solutions in co-development and industrialisation with engineering teams enable providing strong and true support to our four manufacturing sites in France (EINEA, SELHA and LCO) and Morocco (OB in Casablanca).

By grouping together Selha, Einea, OB and LCO, Selha Group is now able to offer its customers services which include cross-board activities (IPC training, electronic lab expertise, mechanical tooling center, on site intervention…), thus ensuring a one to one relationship whilst drawing from the entire group's expertise.